Skin Care – Makise Lifeup USA

JIPANG Ginger PROTEOGLYCAN – 60 Vegetable Capsules

CustomerTeam — Mon, 22 Jan 2024 05:52:00 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

For three decades, our distinguished director, Dr. Makise, has traversed over 85 countries, passionately studying natural substances to bolster health. This journey culminated in the establishment of a clinic in Osaka, Japan. Here, Dr. Makise integrates his unique supplements with his extensive expertise, effectively treating numerous patients contending with intricate health challenges, both domestically and globally. From the forefront of medical innovation, we present products of unparalleled reliability, endorsed by countless users. We are dedicated to consistently delivering supplements that form a dependable cornerstone of your health regimen, safeguarding your well-being today and tomorrow.

What is Proteoglycan?

“Proteo” means protein. “Glycan” means polysaccharide, and proteoglycan is a complex of sugar and protein, and is a type of “Glycoprotein.”

It is the third biological component that forms the extracellular matrix along with hyaluronic acid and collagen.

In the skin, it has excellent water retention and is important for maintaining firmness and elasticity.

In joints, it is contained in cartilage and helps joint movement through its cushioning effect.

Proteoglycans exist widely in the body as extracellular matrices, including in the skin and cartilage.

Proteoglycan is extracted from Salmon nasal cartilage“氷頭 - HIZU"

“Hizu” refers to the nasal cartilage of Salmon, a food with a long history in Japan as recorded in the “Engishiki”, a Japanese book of laws and customs published in 926 AD. This document includes references to “Hizu” being offered to the Imperial Court. Traditionally, “Hizu” is marinated in vinegar and eaten with Japanese radish and carrots, making it a popular New Year’s dish in Japan’s regions. Extracted only in small quantities from Salmon, Hizu remains a rare and treasured delicacy, prized for its uniqueness and taste.

Revolutionary effect of “PROTEOGLYCAN”

Thirty years ago, proteoglycan was a dream-like rare ingredient that cost 30 million yen per gram.

The successful development of Japanese extraction techniques has made it possible to use it as an ingredient in cosmetics and supplements.

Water retention and moisturizing power exceeding hyaluronic acid
Effect of EGF-like action on aging care　
The effect of promoting the production of “Hyaluronic acid”
The effect of promoting the production of “Type I collagen”
Improvement of elasticity and wrinkles, tightening pores, reduction of spots, increase of keratin moisture in human skin.

Discover the versatile benefits of Yuzu (Citrus junos) Seed Extract

Yuzu, an evergreen citrus fruit native to Japan, has been used as part of Japanese cuisine since 800 AD. Yuzu, which is rich in organic acids such as citric acid and tartaric acid and vitamin C, is known for its recovery from fatigue, pain relief, and beauty effects. But Yuzu seeds have even more surprising benefits.

Superior whitening effect compared to vitamin C.
Promotes fibroblast proliferation and aids in skin repair and regeneration.
Inhibits the expression of genes involved in the destruction of key skin components such as hyaluronic acid, ceramide, and collagen. This action helps maintain the skin’s structural integrity, barrier function, hydration, and elasticity.
Significant and potent inhibition of matrix metalloproteinase 1 (MMP1), which is important for maintaining skin quality.

Beyond these skin-focused benefits, yuzu seed extract may help improve metabolic syndrome by reducing stress, promoting blood circulation, increasing good cholesterol, and reducing triglycerides. is shown in the data.

Why JIPANG Ginger PROTEOGLYCAN？

— Embracing Your Body’s Natural Regeneration —

Collagen and Hyaluronic Acid Synthesis: Unique in its ability to naturally stimulate the body’s own production of both Collagen and Hyaluronic Acid, crucial for skin elasticity and hydration.
Enhanced Potency: With a doubled dosage of Proteoglycan, this supplement not only rejuvenates skin but also effectively eases joint discomfort.
Skin Rejuvenation from Within: Unlike topical treatments, it fosters deep, intrinsic skin renewal by encouraging the natural synthesis of vital skin components.
Joint Health Support: Addresses joint health by enhancing cushioning and mobility, demonstrating the compound’s versatility beyond skin care.
Holistic Approach to Wellness: Conceived with the philosophy of internal wellness for external beauty, embodying Dr. Makise’s vision of comprehensive health care.
Natural Potency for Overall Wellbeing: A testament to the power of nature in health, this supplement is a blend of potent natural ingredients for holistic benefits.
Targeted yet Broad-Spectrum Impact: While focusing on skin health and joint support, it simultaneously contributes to overall physical well-being.

JipangGingerProteoglycan Facts

The post JIPANG Ginger PROTEOGLYCAN – 60 Vegetable Capsules appeared first on Makise Lifeup USA.

Symbiotic Water

CustomerTeam — Tue, 03 Mar 2020 05:36:56 +0000

” Symbiotic Water ” Beyond Organic, Towards Symbiosis; A Gift from Japanese Tradition.

” Symbiotic Water ” exerts the following effects on the skin: it whitens, moisturizes, smooths, constricts and revitalizes aged skin, as well as helps the skin recover from damage caused by ultraviolet rays.Our skin hosts more than 1 trillion bacteria (over 10 types) all living in harmony with each other. They create a ” Symbiotic Biosphere “. This is very important for the health of our skin. ” Symbiotic Water ” promotes this harmonious ” symbiosis ” between bacteria and with humans. This unique cosmetic is produced by a doctor (www.drmakise.com) who has treated more than 50,000 patients with various kinds of skin problems. Therefore, ” Symbiotic Water ” can be safely applied on almost all skin types.

No chemical substances are added. All natural. To make ” Symbiotic Water “, a special water is used. First, pure water is filtered by a reverse osmosis membrane. 5 special stones are then dipped into the ultra-purified water. We call this water ” Stone Water “. One stone emits infrared rays at normal temperature, another contains Germanium, and one contains a lot of Magnesium. The other 2 stones generate negative ions. As soon as you put ” Symbiotic Water ” on your skin, you feel the gentle penetration of the liquid deep into the skin. This is due to the effects of ” Stone Water “. It exerts immediately its effects on the epidermis and dermis.

doctor's Skin Care

We deliver products that you can continue to use with peace of mind.

Dr. Tadahiro Makise, the esteemed director of our clinic, has spent over 30 years traveling to more than 85 countries in pursuit of natural substances that enhance health. His journey culminated in the establishment of his clinic in Osaka, Japan.

Dr. Makise has extensively treated patients suffering from chronic skin conditions such as psoriasis, atopic dermatitis, and prurigo nodularis　(nodular prurigo), which are often resistant to conventional treatments. Many of these patients have benefited from unique lotions and ointments developed and manufactured in our clinic in Osaka and our laboratory in Okinawa Japan, effectively addressing various skin issues. We are proud to offer products with unmatched reliability, crafted from years of clinical experience and supported by numerous users and patients.

The 4 traditional herbs

Alpinia zerumbet (Shell Ginger)

his is a tropical perennial plant that grows in some South East Asian nations. It is easily recognizable for its beautiful white flowers in the spring and summer. For centuries it has been used in Okinawa as an ingredient in food and used to wrap traditional rice dumplings. It contains a lot of polyphenols such as quercetin, epicatechin, catechin, kaempferol, arbutin, and more. Arbutin is known to block tyrosinase activity thus preventing the formation of melanin, which leads to a whitening effect. Our shell ginger extract blocks the activities of collagenase, elastase, and hyaluronidase. Consequently, it prevents wrinkled, marked and sagging skin. Read more about Shell Ginger.

Saxifraga stolonifera (Creeping Saxifrage)

This is a perennial flowering plant, native to Asia. It has attractive white blossoms with distinctive pointed petals and a bright yellow ovary. This herb also contains arbutin and has a strong whitening effect. It repairs the damaged DNA by ultraviolet rays. The foliage is used fresh or cooked in Japanese cuisine, and also used as an herbal remedy in Classical Japan. It contains more quercetin than onion.

Sophora flavescens

This perennial plant growing up to 0.5m -1.5 m is widely distributed in Asia, Oceanica, and the Pacific islands. It contains arbutin, kuraninol, kuraridinol, trifolirhizin all of which possess tyrosinase inhibitory activity. It also has a stronger effect of whitening than kojic acid. The roots have been used in traditional medicines for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin disease. It contains an alkaloid, matrine, that inhibits expression of substance P and NK-1R in a human model of skin inflammation.

Hamamelis virginiana

This deciduous plant is also known as witch-hazel. It is native to North America and grows to 5m to 10m tall. Since long ago, native American Indians have been using the leaves and bark of this tree to treat muscle sprain, bruise, burn, muscle pain, stomatitis, throat pain, etc. Nowadays this herb is used to improve varicose veins and hemorrhoids. This effect is due to the anti-inflammatory effect of this tree. And it strengthens capillaries by condensed and hydrolizable oligomeric tannins contained in the bark. And polymeric proanthocyanidins in the bark increases the proliferation of the keratinocytes, which ameliorates scars of the skin. And it contains arbutin and has a strong whitening effect as the above mentioned 3 herbs.

The 5 stones for ” Stone Water “

The most unique idea in the process of the production of ” Symbiotic Water “ is application of ” Stone Water “. This idea is from one of the famous Japanese traditions, the Onsen (hot spring). For thousands of years, the onsen has been loved and used for improving health in Japan. It can be dated back even to the Jōmon period (14000 BC ～300 BC). Samurai soldiers would immerse their wounded bodies into hot springs for its healing properties. Couples who couldn’t have a baby went to the hot springs to improve productivity.
There are more than 3000 hot springs in Japan. And recently the health power of hot springs is re-recognized by many scientists. One of the principal causes of the power comes from the ” Stones “. Hot water filters from the ground running through many different kinds of stones found in the earth. Consequently, the water contains a lot of minerals and well-balanced ions both of which improve our health. The water is absolutely natural but extremely effective to keep our skin healthy. So, we applied the ” Hot Spring Theory ” to the production of ” Stone Water “. As a result, the most unique combination of ” 4 traditional herbs ” and ” Stone Water by 5 stones ” produces excellent ” Symbiotic Water “.

Black Silica: This stone originates only in the mountains of Hiyama in Hokkaido, Japan. It emits far-infrared rays at room temperature as well as negative ions.

Magnesium Ceramic Ball: It contains Magnesium. Magnesium is an essential mineral for normal function of mitochondria.

Germanium Ceramic Ball: 4 electrons are in the outer layer of electron orbital of a germanium atom. One of the 4 electrons shoots out from the orbital at 32℃, and the electron works as an anti-oxidant.

Porous Ceramic Ball and Infrared Ceramic Ball: Both emit negative ions more than tourmaline. Negative ions are known as the ” Vitamin of Air “. Our environment in modern life has a lot of electromagnetic waves filled with positive ions which are known as ” Fatigue Ions “. We need more negative ions to keep the ions in the human body well balanced.

How To Apply

Holding the bottle 20 cm away, thoroughly spray the surface of your skin with ” Symbiotic Water “. Be careful so the water does not get in your eyes.
Use your hands to massage the water into your skin. Add more water to the dryer parts of your skin. The warmth of our palm will help the water to penetrate the skin.
“Symbiotic water” can be applied to any part of the body.

Caution

Do not apply ” Symbiotic Water ” to any skin disorders such as eczema, rash etc –.

If your skin reacts to ” Symbiotic Water ” discontinue use.
If you have an allergic reaction to “Symbiotic Water”, please stop and consult with a dermatologist.
Be careful to not let ” Symbiotic Water ” get on your eyes. In the case ” Symbiotic Water” does get on the eyes, immediately wash out it.
Keep out of the reach of children. Store at room temperature, and away from direct sunlight.
Do not drink ” Symbiotic Water “.
“Symbiotic Water” does not contain any synthetic preservatives, aroma chemicals, artificial colors. All materials originate from natural plants.

Additional Information

Ingredients: Water, Glycerin, 1,3-Butanediol, 1,3-Propanediol, Extract of Alpinia zerumbet, Hamamelis virginiana Distillate, Agar, Extract of Root of Sophora flavescens, Extract of Saxifraga stolonifera, Urea, Silica, Phenoxyethanol, Citrate

Weight: 150ml（5.07fl oz.）

Shipping weight: 230g

Warnings: Keep out of the reach of children, Keep in cool and dry place.

Manufactured by: Makise Lifeup Laboratory Co.,Ltd

Distributed by: Makise Lifeup Laboratory Co.,Ltd

Product of Japan

The post Symbiotic Water appeared first on Makise Lifeup USA.

Water Soluble Oil Soap

CustomerTeam — Tue, 03 Mar 2020 03:03:15 +0000

doctor's Skin Care

We deliver products that you can continue to use with peace of mind.

It may sound counter-intuitive to talk about a water-soluble oil soap as oil is normally insoluble in water. However, a technology developed in Italy allows oil to be soluble in water. Using that technique, we made our soap, whose main ingredients are water-soluble grape seed oil and vegetable squalene.

This soap is excellent when applied to skin that has been inflamed due to diaper rash, atopic dermatitis, allergic eczema and psoriasis. The soap is also excellent for washing off oil ointments that have been used on the skin. It is also very helpful for dry skin and washing off makeup. For seriously inflamed skin, this soap is particularly beneficial because it doesn’t sting. It can be used on the entire body except for the eyes.

After washing the soap off the skin, the oils from the grape seed and jojoba remain on the skin and produce a moisturizing effect. The soap is also excellent for treating dandruff. It should be massaged into the scalp and washed off using water.

Using Method Of Water-Soluble Oil Soap

Wet your body, face, and hands with water.
Shake the bottle of soap lightly and pour some of the liquid soap into your hands.
When the soap is mixed with water, you will feel a gentle warmth.
Apply the soap to your skin. You should use enough soap to thoroughly wet your skin so it does not become abraded by too much friction while you are applying it.
Using your fingers, very gently rub the soap into your skin.
Remove the soap using lukewarm water, although any temperature water will suffice as long as the soap is removed.

The post Water Soluble Oil Soap appeared first on Makise Lifeup USA.

P-I Lotion

CustomerTeam — Thu, 16 Nov 2023 01:38:13 +0000

The Science and Nature Fusion for Beautiful Skin.

Born from the desires of patients at Makise Clinic, the “PI Lotion” is tailored for issues like spots and pigmentation. It effectively inhibits melanin production and targets the root causes of skin troubles, using a special mineral water-based formula designed for skin health.

doctor's Skin Care

We deliver products that you can continue to use with peace of mind.

Key Ingredients:

Proteoglycan: Potent in improving pigmentation (EGF-like action, inhibiting melanin production, promoting hyaluronic acid and type I collagen production).
Placenta: Encourages fibroblast proliferation and offers diverse actions for pigment improvement.
Lactoferrin: A protein found in breast milk, mainly effective in suppressing pigmentation and inflammation.
Sakura (Somei Yoshino) Leaf Extract: Exhibits antihistamine properties and confirmed to inhibit melanin production.
Bilberry Leaf Extract: Suppresses melanin production and stimulates the production of hyaluronic acid.
Hyaluronic Acid: Known for its moisture retention and skin whitening properties.
Shell Ginger Leaf Extract: Contains polyphenols that support skin firmness, luster, and whitening.

How To Apply

Dispense 1-2 pumps of PI Lotion onto your palm and apply it to your face and body.

For areas of concern with dryness, reapply as needed and gently blend into the skin.

Additional Information

Ingredients: Water,1,3-Butanediol,1,3-propanediol (from corn), Glycerin, Sodium Hyaluronate, Alpinia zerumbet Leaf Extract,
Soluble Proteoglycan, Vaccinium Myrtillus Leaf Extract, Prunus Yedoensis Leaf Extract, Phenoxyethanol, Lactoferrin, Placental Protein BG, Methylparaben, Citric Acid

Weight: 150ml/5.07fl oz.

Warnings: Keep out of the reach of the children, For external use only. Keep in cool and dry place. Avoid contact with eyes. Discontinue use if irritation occurs.

Manufactured by: Makise Lifeup Laboratory Co.,Ltd

Distributed by: Makise Lifeup Laboratory Co.,Ltd

Product of Japan

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P-I Lotion is a gentle facial lotion, specially formulated like a beauty serum, to moisturize and improve the appearance of dry, sensitive skin and reduce the appearance of age spots, dullness, and discoloration that become major concerns with aging.

Directions: Take an appropriate amount of lotion onto your hand, Gently apply the lotion onto your face and neck.
Massage your skin in a circular motion until the lotion is fully absorbed.
Use in the morning and at night for best results.

FREE OF: Fragrance, Alcohol, Parabens, Mineral oils, UV absorbing chemicals, dyes
NO TESTED ON ANIMAL

The post P-I Lotion appeared first on Makise Lifeup USA.

Full Skin Care Set

CustomerTeam — Wed, 25 Mar 2020 01:20:12 +0000

doctor's Skin Care

We deliver products that you can continue to use with peace of mind.

For more information about Water Soluble Oil Soap click here >>>>

For more information about Tama Shan click here >>>>

For more information about Symbiotic Water click here >>>>

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