Supplement – Makise Lifeup USA

JIPANG Ginger Optimal – 60 Vegetable Capsules

CustomerTeam — Tue, 25 Feb 2020 01:52:52 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

For three decades, our distinguished director, Dr. Makise, has traversed over 85 countries, passionately studying natural substances to bolster health. This journey culminated in the establishment of a clinic in Osaka, Japan. Here, Dr. Makise integrates his unique supplements with his extensive expertise, effectively treating numerous patients contending with intricate health challenges, both domestically and globally. From the forefront of medical innovation, we present products of unparalleled reliability, endorsed by countless users. We are dedicated to consistently delivering supplements that form a dependable cornerstone of your health regimen, safeguarding your well-being today and tomorrow.

Rich Polyphenols of Shell Ginger(Alpinia zerumbet)

What are Polyphenols?
Polyphenols are a category of naturally occurring compounds found abundantly in plants.
They are a part of the plant’s defense mechanism against disease and also contribute to the color, flavor, and texture of the plant.
Polyphenols are known for their antioxidant properties, which means they can neutralize harmful free radicals in the body.

Benefits of Polyphenols
- Antioxidant Effects: Polyphenols can reduce oxidative stress in the body by neutralizing free radicals,which are compounds that can cause cell damage and contribute to various diseases.
- Heart Health: Consumption of polyphenols has been linked to a reduced risk of heart disease,as they can improve blood vessel function and lower blood pressure.
- Gut Health: Polyphenols can influence gut bacteria in a positive way, promoting a healthy gut microbiome.
- Potential Cancer Prevention: Some studies suggest that polyphenols may play a role in reducing the risk of various cancers, due to their antioxidant and anti-inflammatory properties.
- Blood Sugar Regulation: Certain polyphenols have been found to help in controlling blood sugar levels,which is beneficial for individuals with diabetes or at risk of diabetes.

Types of polyphenols contained in Shell Ginger (Alpinia zerumbet )

Chlorogenic acid – A Natural Antioxidant
Chlorogenic acid is known for its powerful antioxidant properties. It supports weight management by regulating metabolism and reducing carbohydrate absorption. Additionally, it contributes to heart health by maintaining healthy blood pressure levels and improving vascular function.
Ferulic acid – A powerful ally in preventing aging
Ferulic acid, celebrated for its robust antioxidant capabilities, plays a crucial role in anti-aging, cholesterol management, and cancer prevention. Significantly beneficial for skin health, it is a favored ingredient in skincare products. It also counteracts beta-amyloid peptide’s toxic effects, linked to Alzheimer’s disease memory impairment.
Epicatechin – Enhancing Health and Performance
Epicatechin is celebrated for its ability to enhance muscle growth and strength. This potent antioxidant also supports heart health by improving blood flow and reducing oxidative stress. It’s a key ingredient for those looking to boost physical performance and cardiovascular health.
Catechin – The Heart of Green Tea’s Goodness
Catechin, a natural phenol found abundantly in green tea, stands out for its antioxidant properties. It’s known for supporting cardiovascular health, aiding in weight management, and offering potential protective effects against certain types of cancer.
Kaempferol – Nature’s Protector
Kaempferol is known for its powerful antioxidant properties. It supports cardiovascular health, has anti-inflammatory effects, and may reduce cancer risk. Ideal for overall wellness and longevity.
Ellagic acid – Potent Cellular Guardian
Ellagic acid is celebrated for its anti-cancer and anti-inflammatory properties. It promotes skin health, supports cardiovascular function, and aids in DNA repair, making it a vital component for maintaining cellular health and longevity.

What are Urolithins Metabolized by Ellagic Acid?

Urolithins are groundbreaking compounds derived from the digestion of ellagitannins, found in foods like pomegranates, berries, and nuts.

These miraculous molecules have caught the attention of the scientific community for their potent anti-aging properties. They have sparked excitement for their remarkable ability to rejuvenate our cells, making us feel and look younger. These powerful molecules help our bodies to clean out damaged cells, thereby improving our skin’s radiance, boosting muscle strength, and enhancing brain function. With urolithins, we tap into nature’s secret for maintaining vitality and delaying the signs of aging, embodying a holistic approach to health and wellness.

Enhancing the Power of Shell Ginger with an Additional 100mg of Ferulic Acid for Guaranteed Efficacy Within the Body

Ferulic acid is gaining attention for its potential in protecting against Alzheimer’s disease. Research suggests that its antioxidant properties may help mitigate the damage caused by beta-amyloid peptides, the proteins implicated in the development of Alzheimer’s. By possibly inhibiting these peptides’ toxic effects, ferulic acid could play a pivotal role in preserving cognitive function and delaying the progression of this debilitating disease.

The comprehensive benefits of ferulic acid underscore its significance in promoting internal wellness and safeguarding against age-related decline. As we explore its full potential, ferulic acid emerges as a key ally in the pursuit of a healthier, more vibrant life, demonstrating the power of natural compounds in enhancing our well-being from the inside out.

How Shell Ginger's Polyphenols Enhance Gut Health and Urolithin Production

This interplay of Shell Ginger’s polyphenols demonstrates a remarkable synergy within our bodies.
Ellagic acid is converted into Urolithin. However, without a healthy Intestine flora, Urolithin cannot be metabolized.
Quercetin, a powerful polyphenol abundant in Shell Ginger, is known for its research-backed ability to restore and strengthen the health of your intestine microbiome. By modulating the gut flora with quercetin, it supports the metabolic conversion of ellagic acid to beneficial urolithins, demonstrating a sophisticated natural mechanism that promotes health from within. This process is crucial in nurturing our internal ecosystem to enhance health.

Why JIPANG Ginger OPTIMAL？

Experience the profound wellness benefits offered by the diverse polyphenols in Shell Ginger, further amplified by the inclusion of Ellagic Acid (Pomegranate Extract Powder) and Ferulic Acid. This meticulously crafted blend supports your body’s natural defense systems, offering a comprehensive approach to health that spans Alzheimer’s prevention, cholesterol management, and cancer prevention. Our carefully selected ingredients work in harmony to provide a foundation of well-being, imparting a radiance that emanates from within.

The newly formulated JIPANG Ginger OPTIMAL designed to synergize perfectly with JIPANG Ginger WASABI, JIPANG Ginger HIBAMATA, and JIPANG Ginger PROTEOGLYCAN. This advanced blend is crafted to enhance your health and youthfulness more powerfully when combined with any of these supplements. Embrace a stronger support for your wellness journey with the strategic pairing of JIPANG Ginger OPTIMAL and its counterparts.

Supplement Fact

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JIPANG Ginger WASABI – 60 Vegetable Capsules

CustomerTeam — Mon, 21 Aug 2023 02:18:33 +0000

Wasabi Supplement

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

Wasabi

Its valuable rhizome produces a distinctive mix of 21 isothiocyanates, featuring the potent Allyl ITC and the notable 6-(methylsulfinyl) hexyl ITC (6-MSITC), commonly referred to as Wasabi Sulfinyl.

Wasabi Sulfinyl

To date, numerous studies have highlighted the diverse physiological benefits of 6-MSITC, encompassing detoxification, antioxidative, anti-inflammatory, and anticancer properties, as well as improvements in blood circulation and neuroprotection. Recent research has demonstrated its potential in enhancing outcomes for mouse models of Parkinson’s and Alzheimer’s diseases. Furthermore, a clinical study involving 37 healthy men and women who consumed Wasabi Sulfinyl (WS)—a wasabi extract powder with a 0.8% concentration of 6-MSITC—over an eight-week period, reported notable enhancements in participants’ attention and judgment capabilities. Importantly, no adverse effects related to WS were reported. Consequently, WS has been formulated into a health supplement, leveraging its myriad of beneficial effects.

The results of another study underscored the neuroprotective effects of 6-MSITC, showing its ability to normalize oxidative status, positively influence the Nrf2-pathway, reduce apoptosis and neuroinflammation, and facilitate behavioral recovery. These collective insights suggest that 6-MSITC holds potential as a beneficial adjunct in therapies for Alzheimer’s disease.

For further reading

Anti-tumor and Anti-cancer Properties

Research has consistently demonstrated the effectiveness of Wasabi Sulfinyl in combating a variety of tumors and cancer-related conditions. Notably, the anti-tumor properties of 6-MSITC have been observed in various types of cancer, including endometrial carcinoma, breast, skin, pancreatic, colorectal, and blood cancers. It’s important to note, however, that the efficacy of 6-MSITC varies across different cell types.

For further reading

Aging and Brain

Aging affects the brain in several ways, leading to brain shrinkage, changes in blood vessels, and cognitive decline. These effects unfold across different levels, from molecular shifts to structural transformations. Age also heightens the risk of stroke, white matter lesions, dementia, and memory challenges, accompanied by alterations in neurotransmitter and hormone levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596698/

Nonetheless, Shell Ginger presents a potential method for decelerating the aging process. Integral to Okinawa, Japan’s diet—where there’s notable longevity among residents and lower occurrences of cardiovascular diseases, strokes, and cancer—Shell Ginger has shown promising results. Research, including studies on worms, indicates that Shell Ginger may boost lifespan by an average of 22.6%. Laden with a rich mix of polyphenols such as Chlorogenic acid, Ferulic acid, Quercetin, Epicatechin, Catechin, and Kaempferol, Shell Ginger emerges as a potent source of health-enhancing compounds.

Thus, the combined power of Shell Ginger and Wasabi in JIPANG Ginger Wasabi holds the promise of significantly bolstering health.

Wasabi Supplement facts

Other Ingredients
HPMC (Vegetable capsule)
Package Quantity
60 capsules
Suggested Use
2 capsules daily with or without food. If your stomach is sensitive, please take these supplements after meals or with meals.

Caution

⁃ Consult with a licensed physician, pharmacist, naturopath, or other qualified healthcare professional prior to taking dietary supplements.
⁃ Consult your healthcare practitioner if you are under the age of 18, have a medical condition, or are pregnant, lactating, or trying to conceive. Keep out of the reach of children. Store tightly closed in a cool place, dry place.

The post JIPANG Ginger WASABI – 60 Vegetable Capsules appeared first on Makise Lifeup USA.

JIPANG Ginger HIBAMATA – 60 Vegetable Capsules

CustomerTeam — Thu, 28 Dec 2023 20:54:50 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

Discover the New Potential of Ascophyllan HS: Natural Appetite Control & Weight Management

Ascophyllan HS, derived from the nutrient-rich seaweed Ascophyllum nodosum, has long been recognized for its immune-boosting and health-supporting properties. Now, groundbreaking research has unveiled an exciting new benefit: its ability to naturally stimulate the release of GLP-1 (Glucagon-Like Peptide-1), making it a revolutionary ingredient for healthy appetite control and weight management.

Why Choose Ascophyllan HS for Weight Management?

A Natural Approach to GLP-1 Stimulation:
Unlike synthetic GLP-1-based medications, Ascophyllan HS offers a gentle and natural alternative. By promoting GLP-1 production, it helps regulate appetite and supports healthy digestion — all without the risks of side effects often associated with pharmaceutical solutions.
Safe and Effective for Daily Use:
Clinical studies suggest that 100mg of Ascophyllan HS per day is sufficient to stimulate GLP-1 release, making it an ideal daily companion for those aiming to achieve their weight management goals while maintaining their overall health.
Supports a Balanced, Healthy Lifestyle:
When combined with a balanced diet and regular exercise, Ascophyllan HS can help you achieve your desired weight in a sustainable and natural way, promoting long-term wellness and vitality.

Perfect for Those Seeking a Holistic Approach to Wellness

If you’re looking for a safe, side-effect-free option to support your weight management journey, Ascophyllan HS is the solution. By harnessing the power of nature, this innovative ingredient empowers you to take control of your health without compromising your body’s natural balance.

Make the Shift to Smarter, Natural Weight Management

Discover how Ascophyllan HS can help you achieve your goals while supporting your body’s natural processes. Combined with the power of Shell Ginger (Alpinia zerumbet), JIPANG Ginger HIBAMATA offers a unique and science-backed solution to healthy appetite control and overall well-being.

What is HIBAMATA?

Hibamata is a type of seaweed primarily found in rocky coastlines of the North Sea and the Atlantic Ocean, where the water is cold. While it has been traditionally consumed as tea and in other forms in Europe for a long time. From this Hibamata family, a functional food ingredient named Ascophyllan has been extracted from the seaweed Ascophyllum nodosum.

Revolutionary Functional Food Ingredient "Ascophyllan”

Derived from the vigorous Ascophyllum nodosum, Ascophyllan is a novel ingredient distinct in composition and structure from Fucoidan and is expected to have benefits such as infection prevention through its immune-boosting properties and blood sugar level control using intestinal hormones.

Its marine-derived polysaccharides, surpassing Fucoidan in efficacy, are shown to potentially prevent various health issues.

Ascophyllan is a Natural Boost for Your Immune System and Blood Sugar Control

Ascophyllan, a dynamic natural compound, activates dendritic and NK cells, fortifying the body’s immune defenses. Celebrated for its antiviral attributes, it stands as an effective ally in the prevention of illnesses like influenza, enhancing your body’s resilience against common pathogens.

Beyond its immune-boosting capabilities, Ascophyllan plays a pivotal role in metabolic health. By inhibiting intestinal α-glucosidase and stimulating GLP-1 secretion in the small intestine’s L cells, it helps in regulating blood sugar levels. This dual action not only suppresses postprandial blood sugar spikes but also maintains lower average blood sugar levels. Additionally, it contributes to the reduction of critical health indicators such as HbA1c values, offering a comprehensive approach to managing blood sugar health.

Why JIPANG Ginger HIBAMATA？

JIPANG Ginger HIBAMATA is not just a supplement; it’s a synergistic blend of nature’s finest, offering a unique combination of health benefits.

Immune Support: Powered by Ascophyllum, it strengthens your immune defense.
Blood Sugar Management: Assists in regulating blood sugar levels for overall well-being.
Rich in Polyphenols: Packed with antioxidants from Shell Ginger, promoting skin health.
Inspired by Okinawa: Embraces the longevity secrets of a region known for its vitality.
Holistic Health Benefits: Aids in metabolic health and enhances general wellness.

Choose JIPANG Ginger HIBAMATA for a balanced approach to health, combining tradition and modern science.

For a more detailed explanation, it would be good to watch the YouTube video.

( Refer to the materials of Company Hayashikane Sangyo Co.,Ltd. )

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JIPANG Ginger PROTEOGLYCAN – 60 Vegetable Capsules

CustomerTeam — Mon, 22 Jan 2024 05:52:00 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

What is Proteoglycan?

“Proteo” means protein. “Glycan” means polysaccharide, and proteoglycan is a complex of sugar and protein, and is a type of “Glycoprotein.”

It is the third biological component that forms the extracellular matrix along with hyaluronic acid and collagen.

In the skin, it has excellent water retention and is important for maintaining firmness and elasticity.

In joints, it is contained in cartilage and helps joint movement through its cushioning effect.

Proteoglycans exist widely in the body as extracellular matrices, including in the skin and cartilage.

Proteoglycan is extracted from Salmon nasal cartilage“氷頭 - HIZU"

“Hizu” refers to the nasal cartilage of Salmon, a food with a long history in Japan as recorded in the “Engishiki”, a Japanese book of laws and customs published in 926 AD. This document includes references to “Hizu” being offered to the Imperial Court. Traditionally, “Hizu” is marinated in vinegar and eaten with Japanese radish and carrots, making it a popular New Year’s dish in Japan’s regions. Extracted only in small quantities from Salmon, Hizu remains a rare and treasured delicacy, prized for its uniqueness and taste.

Revolutionary effect of “PROTEOGLYCAN”

Thirty years ago, proteoglycan was a dream-like rare ingredient that cost 30 million yen per gram.

The successful development of Japanese extraction techniques has made it possible to use it as an ingredient in cosmetics and supplements.

Water retention and moisturizing power exceeding hyaluronic acid
Effect of EGF-like action on aging care　
The effect of promoting the production of “Hyaluronic acid”
The effect of promoting the production of “Type I collagen”
Improvement of elasticity and wrinkles, tightening pores, reduction of spots, increase of keratin moisture in human skin.

Discover the versatile benefits of Yuzu (Citrus junos) Seed Extract

Yuzu, an evergreen citrus fruit native to Japan, has been used as part of Japanese cuisine since 800 AD. Yuzu, which is rich in organic acids such as citric acid and tartaric acid and vitamin C, is known for its recovery from fatigue, pain relief, and beauty effects. But Yuzu seeds have even more surprising benefits.

Superior whitening effect compared to vitamin C.
Promotes fibroblast proliferation and aids in skin repair and regeneration.
Inhibits the expression of genes involved in the destruction of key skin components such as hyaluronic acid, ceramide, and collagen. This action helps maintain the skin’s structural integrity, barrier function, hydration, and elasticity.
Significant and potent inhibition of matrix metalloproteinase 1 (MMP1), which is important for maintaining skin quality.

Beyond these skin-focused benefits, yuzu seed extract may help improve metabolic syndrome by reducing stress, promoting blood circulation, increasing good cholesterol, and reducing triglycerides. is shown in the data.

Why JIPANG Ginger PROTEOGLYCAN？

— Embracing Your Body’s Natural Regeneration —

Collagen and Hyaluronic Acid Synthesis: Unique in its ability to naturally stimulate the body’s own production of both Collagen and Hyaluronic Acid, crucial for skin elasticity and hydration.
Enhanced Potency: With a doubled dosage of Proteoglycan, this supplement not only rejuvenates skin but also effectively eases joint discomfort.
Skin Rejuvenation from Within: Unlike topical treatments, it fosters deep, intrinsic skin renewal by encouraging the natural synthesis of vital skin components.
Joint Health Support: Addresses joint health by enhancing cushioning and mobility, demonstrating the compound’s versatility beyond skin care.
Holistic Approach to Wellness: Conceived with the philosophy of internal wellness for external beauty, embodying Dr. Makise’s vision of comprehensive health care.
Natural Potency for Overall Wellbeing: A testament to the power of nature in health, this supplement is a blend of potent natural ingredients for holistic benefits.
Targeted yet Broad-Spectrum Impact: While focusing on skin health and joint support, it simultaneously contributes to overall physical well-being.

JipangGingerProteoglycan Facts

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Total Vitality Pack

CustomerTeam — Wed, 06 Mar 2024 05:46:05 +0000

For more information about JIPANG Ginger OPTIMAL https://makiselifeup.com/product/jipang-ginger/ For more information about JIPANG Ginger PROTEOGLYCAN https://makiselifeup.com/product/jipanggingerproteoglycan/

For more information about JIPANG Ginger WASABI https://makiselifeup.com/product/ginger-wasabi/

For more information about JIPANG Ginger HIBAMATA https://makiselifeup.com/product/jipanggingerhibamatasupplement/

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

The post Total Vitality Pack appeared first on Makise Lifeup USA.

JIPANG Ginger Powder (60g) – Powder

CustomerTeam — Wed, 10 Jun 2020 05:29:51 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

Shell ginger (Alpinia zerumbet is the botanical name) is a tropical perennial plant that grows in abundance in Okinawa and continues to be used in traditional Okinawan cuisine and as a traditional remedy. The leaves of shell ginger come in two forms – deep green and gold striped. It blooms amazing yellow flowers around July and white blossoms in early summer. Shell ginger has a long and respected history.

You may not be familiar with the plant called “Shell Ginger” (Alpinia zerumbet). Shell ginger is different from ordinary ginger. Please don’t confuse shell ginger with ordinary one. Very much different in health benefits. Because it grows in Okinawa’s subtropical climate, it has thousands of phytochemicals that protect itself from strong sunlight.

For 12 years, we have been producing health supplements from this plant. Our brand name is “JIPANG Ginger” which helps thousands of people to maintain and improve their health and vitality not only in Japan but also all over the world. And recently, we started to offer two kinds of JIPANG Ginger.

Shell Ginger leaves fermented into powder (Capsule type) – more info>>
Simple powder of shell ginger leaves (Powder Type)

Does Shell Ginger Promote Longevity?

With a life expectancy of 84.55 years in 2019, Japan always on the top list when it comes longest life expectancy. Many longest-living people of Japan are from Okinawa where many residents are over 100 years old. Among the many reasons contributing to their longevity, nutrition and the “Okinawan diet” are said to be key elements for highest life expectancy and healthy lives in Okinawa

So what exactly makes the Okinawan diet special?

One local ingredient, called shell ginger(Alpinia zerumbet), has become the focus of different studies and can be said to be a substantial contributor to longevity in Okinawa. Shell ginger has been used for various purposes in the lives of people living in Okinawa. Leaves of shell ginger have long been used as packing materials for rice cakes (Mochi) and custom to eat it to pray for good health.

Okinawa Mochi Wrapped in Shell Ginger leaves

High in Antioxidants

JIPANG Ginger has outstanding antioxidant properties. Antioxidants act as “shields” for our bodies from free radicals. Antioxidants help us fight the free radicals that cause aging. Free radicals are one of the reason we age, and they cause our bodies to burn through energy faster and slow down our metabolism.

It is thought that free radicals can attack the cells in our body. They can cause cell damage and may also be linked to various other diseases. If you are not getting enough antioxidants in your diet, this can lead to oxidative stress, which can eventually lead to cell damage and risk of developing cancer, heart disease, and many other chronic illnesses and health problems.

Full of Healthy Polyphenols - 34 Times more Polyphenols than Red Wine

Shell ginger contains 34 times more polyphenols than red wine, which makes our JIPANG Ginger lifesaver supplement. The compounds in the polyphenols act like anti-inflammatory agents that stop the growth of inflammatory cells that cause inflammation. When the amount of polyphenols is increased, this makes the body’s inflammatory response to particle exposure much more effective. These same compounds also protect us from other health problems, like cardiovascular disease and cancer. They help keep us out of danger since they limit the growth of many of the carcinogens that are usually involved in cancer cells’ growth. This is why polyphenol intake is said to be an important component of a healthy diet.

Focusing on the traditional fermentation technique, we fermented Shell Ginger with the fungus “Aspergillus niger”. So, we discovered that some phytochemicals were significantly increased. We don’t know exactly how the many phytochemicals such as polyphenols, terpenoids, kava pyrones, phenylpropanoids, sterols, etc. are absorbed in the intestine.

For example, polyphenol here is 8000 types, and their absorption rates from the intestinal tract are all different. In general, its absorption rate is generally not high. The absorption rate of flavanol, chalcone, and isoflavone is about 5 to 30%. As the amount of these polyphenols increases due to fermentation, the amount of polyphenols in the blood also increases. So the anti-obesity, anti-oxidant, anti-glycation, anti-platelet, osteogenic, and neuraminidase inhibitory activities are enhanced.

Shell ginger also contains carotenoids. Carotenoids have a low absorption rate of 0.1% to a few%, but if you eat a lot of them, most of them will be taken into the body in proportion to the amount you eat. Although still in the research stage, some carotenoids in shell ginger are significantly increased by fermentation. Carotenoids have various health-promoting effects similar to polyphenols.

However, there should be beneficial enzymes and nutrients that are destroyed by fermentation. For example, curcumin in turmeric exhibits a liver function-improving effect. But curcumin must be metabolized to tetradehydrocurcumin by a special enzyme to exert its effect. If the enzyme is destroyed, curcumin is useless. (Please don’t worry. This enzyme is not decomposed by fermentation because it exists in the epithelial cells in the intestine. I just write an example.)

Good Sources of Dietary Fiber

Dietary fiber is a good thing for your body. It helps to prevent the buildup of toxins in your system. Without dietary fiber in the diet, you can be at risk for irritable bowel syndrome, colon cancer, dyslipidemia, constipation, obesity, diabetes, etc. Fiber will enable your body to be able to absorb the food that you eat much more easily, thereby eliminating that problem that we talked about before. Another good thing about fiber is that it allows you to feel full faster. This allows you to eat less overall and still have enough nutrients for the rest of your day.

Shell ginger powder contains as much as 60% dietary fiber. So it is a good source of dietary fiber.

Various Ways to Drink and Eat Shell Ginger

We use only Okinawa shell ginger leaves which are carefully chosen. Since shell ginger is processed to powder, then it can be mixed with Western confectionery such as cakes, ice cream, yogurt, jelly as well as other foods. Polyphenols generally do not stay long in the body after being absorbed in the intestine. At best, for 2 to a few hours. Therefore, if you want to get the best effect of polyphenols, you should take it every few hours. For that, you are encouraged to drink shell ginger tea just like coffee. Both types – fermented type and non-fermented simple type – are OK for tea.

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Red Vine Leaf – Healthy Vein Circulation 120 capsules (30 capsules x 4 packets)

CustomerTeam — Wed, 27 Jan 2021 03:37:29 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

Manufactured in the Swiss highlands, our supplement Red Vine Leaf extract is a lot more than just an ordinary powder of grape leaves. Rich in polyphenols such as Anthocyanins and Resveratol, our supplement not only alleviates conditions such as swelling legs (edema), joint pain, and varicose veins, but also:

Increase visual awareness
Reduce blood pressure
Help provide symptomatic relief of Chronic Venous Insufficiency (CVI)
Restrict tumor formation
Prevent diabetes
Improve cognitive and motor functions

Unlike other similar products, our Red Vine Leaf supplement is exceptionally made from a proportionate amount of polyphenols. Each capsule contains an equal amount of polyphenol powder on each capsule. This means every capsule is as much effective as every other capsule. This is rarely the case with other similar products.

Vitis vinifera, the common grapevine

Vitis vinifera, the common grapevine, is a sarmentose, potent, high-powered shrub with climbing stems. It has been documented for its application in winemaking more than 3,500 years ago. The production of grapes is recognized as commercially significant, primarily related to wine production, juices, raisins, and other food products. In addition to their lucrative potential, grapes and their byproducts exhibit nutritional and functional properties.

There is a saying in Germany that goes, ‘Healthy veins and legs are like the daughter of a winery!’ (GusundeVenen un. Schoene Beinen wie ein Winzer). Also, in Italy, it has been long said that ‘Good wine makes good blood!’ (Buon vino fa buon sangue). In Indian Medicine, the grape is used for headache, dysuria, scabies, skin disease, gonorrhea, hemorrhoids, and vomiting [PDR for herbal Medicines 2004]. Over the centuries, red vines have been known for therapeutic purposes and in treating conditions like diarrhea, skin disorders, bleeding, hemorrhoids, varicose veins, and other circulatory diseases.

The alchemy behind Red Vine Leaf extract

Our Red Vine Leaf extract is magical, but the polyphenols it contains: Anthocyanins and Resveratrol, are even more so. The quantitative components of the extract are:

Polyphenols 30% or more
Anthocyanins 0.40 to 1.60%
Trans-Resveratrol 5-30 mg / 100 g (HPLC)

A type of flavonoid, Anthocyanin, is a life-saver when it comes to heart health. By improving blood sugar and cholesterol levels, it takes care of your heart with all the protection it needs. Adding to that, it has been reported to lower blood pressure by a statistically significant number.

On a more micro-level the benefits of polyphenol are countless. Starting from improved visual awareness Anthocyanin improves motor functions, prevents diabetes, restricts the growth of tumors, and prevents obesity. Similarly, it is also antibacterial and anti-inflammatory in nature, which prevents diseases by inhibiting the growth of microorganisms.

One study conducted in 2010 even concluded that Anthocyanin might help in the prevention of breast cancer. Although there’s more research to be done, it shows how promising the polyphenol could be on our overall well-being.

Another polyphenol, Resveratrol, is on a different level altogether. Studies show that it prevents Alzheimer’s by preventing the damage of nerve cells and by reducing the buildup of plaques in the brain. However, its influences extend beyond that. It has also been known to prevent heart attack and stroke by inhibiting the formation of clots and prevent cancer by restricting the growth of cancer cells.

How Red Vine Leaf Heals Your Varicose Veins and Helps Prevent Edema?

As mentioned, the Red Vine Leaf contains polyphenolic derivatives, namely anthocyanins, leuco-anthocyanins, and flavonoids. Due to the presence of such natural antioxidants, vine leaves inhibit pro‐oxidant enzymes, reduce platelet aggregation, promote vasodilation, and decrease the resistance to blood flow. They help to improve circulation and reduce the feeling of tired and heavy legs likewise.

Red Vine Leaf extract maintains the endothelial lining of tiny capillaries, promotes their repair, and reduces permeability. This reduces the leaking of fluids into the tissues during blood circulation. As a result, the swelling of surrounding tissues (edema) does not occur.

It lowers low-density lipoprotein (LDL or bad cholesterol) levels and relaxes the blood vessels. Similarly, it protects and repairs vascular endothelial cells, suppresses plaque formation, and prevents cardiovascular diseases. It also helps to draw tissue together, supporting the arrest of bleeding and diarrhea. These synergistic actions also aid in the cure of varicose veins as well as in the reduction of conditions such as painful and heavy legs.

These extracts have been shown to:

Improve lower leg blood flow
Help reduce swelling (lower leg edema)
Help provide symptomatic relief of CVI
Helps ease problems related to poor circulation.
Lessens feelings of tiredness & heaviness in legs.

Human clinical trial in Japan: Effect of Red Vine leaves on reducing the swelling of lower legs.

In a placebo-controlled clinical study conducted in Japan, a few researchers tested the effect of Red Vine Leaf powder on 17 middle-aged, healthy women. The women, who were painfully aware of their swelling legs, were given 3 capsules (600mg) of Red Vine Leaf every day after breakfast. In contrast to that, the placebo group was given 250mg of filler capsules.

After six weeks, the research found something drastic. Compared to the placebo group, the participants’ swelling was reduced by a whopping 4 times (56%). Not only that, but the researchers found no side-effects of the supplement whatsoever.

The amount of dried red vine leaf powder in the capsules used in this test was 200 mg and the human clinical intake was 600 mg of 3 capsules daily. However, our capsule contains 225 mg of Red Vine Leaf dry powder, which indicates 2 capsules are 450mg and 3 capsules are 675mg.

Please take 2-3 capsules per day for better results.

Many patients encountering varicose veins don’t often consult a doctor right away, as they’re easy to forget when they aren’t painful. But in reality, varicose veins generally get more critical over time and can lead to serious health risks. Many people who don’t treat their vein disease will experience signs of pain, fatigue, and swelling of the legs or ankles. More advanced medical complexities include hyperpigmentation, venous leg ulcers, spontaneous bleeding, superficial thrombophlebitis, and a likely life-threatening condition termed deep vein thrombosis. It can also lead to the impairment of capabilities like running and walking normally.

However, the harm caused by untreated CVI and Varicose veins is preventable. This is even true if you make certain lifestyle modifications to control them and manage your pain. Red Vine Leaf alleviates the symptoms and provides effective relief by improving the blood flow in the lower legs, reducing the swelling, and keeping your legs and veins healthy.

What’s even more, our Red Vine Leaf extract, the beneficiary antioxidants, and constantized polyphenols boost the overall functioning and maintenance of the body, thereby making them more effective than other similar supplements.

Supplement Facts

Serving size: 2 capsules
Servings per container: 30

Red vine leaf dried extract: 450 mg

Other Ingredients
HPMC(Vegetable capsule), Crystalline cellulose, Gum arabic, Sucrose fatty acid ester, Coloring (Titanium dioxide)

Package Quantity
60 capsules (30 capsules x 2 packets)

Suggested Use
2 to 3 capsules per day, or as directed by your qualified healthcare professional.

Caution
⁃ Consult with a licensed physician, pharmacist, naturopath, or other qualified healthcare professional prior to taking dietary supplements.
⁃ Consult your healthcare practitioner if you are under the age of 18, have a medical condition, or are pregnant, lactating, or trying to conceive. Keep out of the reach of children. Store tightly closed in a cool place, dry place.

The post Red Vine Leaf – Healthy Vein Circulation 120 capsules (30 capsules x 4 packets) appeared first on Makise Lifeup USA.

Proteor GII (Proteoglycan supplement) – 90 Tablets

CustomerTeam — Wed, 16 Mar 2022 07:08:54 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

If you heard that the nose of salmon heals your joints and skin, would you find it ridiculous? Maybe yes. But, surprisingly, now the Japanese researchers of Hirosaki University have proven that the nose of a salmon can heal your joints and skin.

For more than 1000 years, in the northern provinces of Japan, including Hokkaido, Aomori, Iwate, and Niigata Prefecture, people eat salmon head as a delicacy to celebrate the New Year. The Japanese called this specialty as Hizu Namasu.

Due to its clear and transparent look, people call the nasal cartilage of salmon “Hizu” in Japan. “Hizu” in Japanese means ice head. The head of a raw salmon fish is thinly-sliced, soaked in salt and vinegar, and then mixed with julienned Japanese radish with seasonings.

The main component in the cartilage of salmon’s nose is Proteoglycan (PG), which is an effective supplement for joint and skin problems. Until a few years back, PG cost 30 million Yen (~ $250 thousand) to extract just 1g of PG from the salmon’s nose. While now, with the development of unique manufacturing and mass-production methods, the cost of PG is reasonable. It is now available as a health supplement.

What is Proteoglycan?

Proteoglycans (PG) are naturally-occurring glycoproteins in the human body. These proteins have glycosaminoglycans attached to the core protein. They make up a significant part of the extracellular matrix and maintain body tissues. It is a component that retains plenty of water like a sponge in articular cartilage and has a cushioning function. Hence, proteoglycan absorbs shock and impact.

What are Proteor-GII supplements made up of?

Our Proteor-GII uses the extract of salmon nasal cartilage. The entire processing from catching the fish to extraction takes place in Japan. Heretofore, it was challenging to isolate PG with high purity. Then, a research group of Hirosaki University in Japan developed a refining technology of high purity Proteoglycans on a large scale.

Health benefits of Proteoglycan

Did you know the human body has more than 200 bones? And more than 200 joints that connect these bones? Just imagine that these parts work together to allow us to walk, run, jump, eat, sleep, and perform all the activities in our life.

Your knees are the largest joint in the body. They bear a lot of weight and have a great responsibility for your ability to move. They also contain locomoting parts, from ligaments and cartilage to muscles and bones. These parts can become damaged either from injury or the natural wear and tear of age, making it problematic to stay active and do daily activities.

Proteoglycan is the main component contributing to the elasticity of the articular cartilage

Articular cartilage covers the ends of the long bones, where they come together to form joints. About 70% of the components that make up articular cartilage are water. The remaining 30% are type II collagen, proteoglycan, and hyaluronic acid.
Type II collagen maintains the structure of cartilage. Collagen is a protein that serves as the basis for the connective tissue of all organs. With aging, the production of collagen declines and leads to aging of the skin and joint problems.

Composition of Articular cartilage

A large amount of PG in articular cartilage contains glycosaminoglycans (GAGs). Glycosaminoglycan chains have a moisture-holding function like a sponge. Due to its high water retention capacity, it plays a role in the stretching and bending of cartilage. Thus, PG has a cushioning effect and improves the function of joints.

Proteoglycan supports joint movement

In one trial published in the Japan Pharmacology and Treatment journal, the randomized and double-blind study recruited 53 participants with knee osteoarthritis but otherwise healthy.

The study used the Japanese Orthopaedic Association (JOA) score to evaluate knee joint function. In this study, the assessment was on the basis of pain during walking, stair climbing, and swelling. This study confirmed that PG derived from salmon nasal cartilage could relieve pain and support joint health. The study also assessed safe intake and found no adverse effects of consuming proteoglycan.

http://www.pieronline.jp/content/article/0386-3603/45020/255

Proteoglycan supplement has shown promising benefits, especially in the case of osteoarthritis.

Osteoarthritis is the most common joint disorder. It occurs when the cartilage between two joints wears down. As an impact, the bones rub together and result in swelling and stiffness. The loss of PG from articular cartilage is a hallmark in the development of osteoarthritis. Moreover, with age, the PG undergoes a gradual decrease in the cartilage.

Proteoglycans reduce the risk of osteoarthritis. They significantly induce cartilage differentiation and suppress cartilage calcification and decomposition. These actions can have a positive effect in alleviating the symptoms of osteoarthritis.

Bertrand J., Held A. (2017) Role of Proteoglycans in Osteoarthritis. In: Grässel S., Aszódi A. (eds) Cartilage. Springer, Cham.

Along with joint health, Proteoglycan has several physiological functions

Proteoglycan is known to have epidermal cell growth (EGF) mimicking region on the C−terminal part of the core protein. Proteoglycan obtained from salmon nose cartilage also has a similar effect. In addition, PG also has the effect of promoting the production of hyaluronic acid and collagen.

The application test of Proteoglycan on human skin showed activities and functions to reduce wrinkles and boost skin elasticity. Proteoglycan promotes the growth of the epidermal cell and improves Type I Collagen and Hyaluronic acid.

In a randomized, double-blind, controlled study, the effect of ingestion of salmon nasal cartilage-derived Proteoglycan on skin condition in healthy adult volunteers was carried out. This study demonstrated the ability of ingested Proteoglycan to improve skin condition, including skin elasticity, wrinkles, pores, moisture, and smoothness. Thus, the results suggested the potential of salmon proteoglycan as a health supplement. https://www.eurekaselect.com/article/70300

In addition to this, Proteoglycan has an inflammation suppressing effect. It has direct and indirect interactions with various cytokines, growth factors, cell surface receptors, enzymes, and glycoproteins within the cell matrix.

Proteoglycan and its metabolites may exert anti-inflammatory actions via the suppression of inflammatory cytokine production. Consequently, they can have a preventive effect, especially against inflammatory diseases. This is for the reason that Proteoglycan is an effective supplement for osteoarthritis.

Other benefits of Proteoglycans

Proteoglycan as a health supplement has various health effects on the body:

Has an antioxidant and firming effect on the skin.
Suppresses the decomposition of cartilage components and protects articular cartilage
Ideal for dry skins.
Reduces pore sizes and eliminates stings after shaving.
Stimulates the synthesis of collagen and hyaluronic acid.
Hydrates and moisturizes skin deeply.
Supports joints movements such as bending and stretching
Makes the cuticle of nails stronger.
Provides nutrients to the extracellular matrix.
Has an anti-inflammatory effect.
Improves age-related skin problems by holding large amounts of moisture.
Has a reparative effect and has wrinkle prevention action.

Is Proteoglycan different from Collagen or Hyaluronic acid?

Yes, they are different from Proteoglycan.

Collagen is a primary component of the cartilage and provides strength to the extracellular matrix. It is responsible for the tightness, firmness, proper humidity, elasticity, and constant renewal of skin cells.

Hyaluronic acid forms a water-soluble gel. It is a structural component of articular cartilage and is responsible for skin smoothness. Hyaluronic acids make the extracellular matrix more flexible.

Proteoglycan has EGF-like activities to accelerate the regeneration of skin cells. In addition, it has functions to synthesize Collagen and Hyaluronic acid. PG has 30% more ability to preserve water than Hyaluronic acid. Because the molecular weight of PG is smaller than that of Hyaluronic acid, it penetrates deeper into the skin.

Should I take Glucosamine for my osteoarthritis?

Glucosamine is a glorified supplement for osteoarthritis because of its effectiveness. Our body utilizes its metabolic product as a part of glycosaminoglycans (hyaluronic acid). Therefore, if you take Proteoglycan, you don’t need to take Glucosamine.

Other Ingredients
Crystalline cellulose, Calcium stearate, Fine silicon dioxide, Maltitol
Package Quantity
90 tablets
Suggested Use
3 tablets daily with water, or chew as it is.

Caution

The post Proteor GII (Proteoglycan supplement) – 90 Tablets appeared first on Makise Lifeup USA.

Doctors Mega Lactoferrin – 120 Enteric-coated tablets

CustomerTeam — Wed, 09 Feb 2022 07:58:50 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

We Have Taken Lactoferrin Since Our First Feed.

Breastfeeding is one of the most effective ways to ensure child health, especially in the first year of their life. When it comes to breastfeeding, we cannot and should not forget about colostrums.

Colostrum is a thick and yellowish fluid that precedes breast milk and is the first liquid that breastfeeding babies drink. It is unduly special for a baby in the first few days of life because it has various antibodies, antibacterial, and antiviral agents that protect against different infections and allergies. Colostrum contains a peculiar protein called lactoferrin, necessary for establishing the baby’s immune system. It also helps babies absorb the iron from breast milk.

What is Lactoferrin?

Lactoferrin (LF) is a red glycoprotein found in breast milk. It is also present in exocrine secretions such as tears, nasal fluid, saliva, and gastrointestinal fluid. However, the best source of lactoferrin is colostrum and contains the highest concentrations. For the first week after birth, breastfeeding babies receive between 7 g (=7000 mg) and 10 g (= 10,000 mg) of lactoferrin from colostrum.

Lactoferrin has a strong binding effect on heavy metal ions, particularly iron and copper ions. LF binds to iron quickly and changes its color to red. Hence, after the discovery of lactoferrin, it was called red protein.

Lactoferrin (lacto=milk, ferrin=iron) is a valuable bioactive ingredient that influences biological processes in the human body to provide potential health benefits.

Enhances the immune system
Has anti-inflammation and anti-cancer properties
Supports iron absorption
Anti-bacterial, anti-fungal, antiviral properties
Promotes bone health
Helps with dry eyes
Potential preventative adjunct for COVID-19
Prevents damage related to aging

The first immunization of humans

Rich in antibodies, proteins, and other essential nutrients, colostrum serves as the first vaccination for the baby. It protects the baby in various ways, promotes the formation of a healthy gut, and is a natural elixir of life. If we take a closure look, lactoferrin is the main hero within the molecular arsenal of immunity.

Lactoferrin acts as the first line of defense on the immune system, both as a weapon and a moderator. It bridges innate and adaptive immune functions. LF can activate the immune system via cytokine-like signals, causing it to produce antibodies and can intensify natural killer cell activity to enhance immune defense. It is also one of the first factors released by neutrophils upon encountering pathogens.

LF influences the immune cells as most of these cells have LF receptors. It can exert changes on white blood cells by increasing natural killer cells, neutrophils, and macrophage activities. Consequently, the production of cytokine and nitric oxide increases.

Lactoferrin has shown potential in fighting viral and bacterial infections. It also acts as an anti-inflammatory agent. Belonging to the transferrin family, LF has iron-binding properties and maintains the cellular level of iron.

https://www.jpeds.com/article/S0022-3476(16)00294-8/fulltext
A research group at Tottori University in Japan had researched neonatal pigs. They found that, in the newborn piglets, the concentration of lactoferrin in the cerebrospinal fluid increased after the administration of colostrum. The blood-brain barrier (BBB) separates circulating blood and cerebrospinal fluid. The study, in contrast, found that oral administration of lactoferrin transferred to cerebrospinal fluid.

Interestingly, the transportation rate further increased in the post-weaning growth stage and not in the neonate. LF is one of the very few proteins that can effectively pass through the BBB. That is why it may alleviate mental stress and nighttime anxiety.

J Vet Med A Physiol Pathol Clin Med. 49 358-364 2002

Lactoferrin and its iron-binding properties

Iron is essential for many physiological processes in the body. However, it can be potentially harmful in overabundance. It can act as a nutrient for microbial pathogens and promote free radical-induced cellular damage when in excess. Therefore regulation of iron homeostasis is crucial and is primarily regulated at the absorption site in the small intestine.

The iron-binding ability of lactoferrin naturally supports its function in intestinal iron absorption. It belongs to the transferrin family that helps increase iron absorption in the intestine and is also responsible for the delivery of iron to cells.

Its iron-binding capacity also inhibits the growth of several pathogenic bacteria. LF hinders the use of iron necessary for bacterial survival and disrupts the multiplication of these bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1793702/

Antimicrobial properties of lactoferrin

Lactoferrin has antimicrobial properties against bacteria, viruses, and fungi. Thus, it is a vital component of the non-specific immune system.

Lactoferrin can prevent bacteria from taking up iron, essential for their functioning. LF can block bacteria’s carbohydrate metabolism and destabilize their cell walls. Besides a broad antimicrobial spectrum against bacteria and fungi, LF also inhibits the replication of a wide range of viruses.

The antiviral activity of lactoferrin is active in the early phase of infection. LF is effective against DNA and RNA viruses, including rotavirus, herpes viruses, and HIV. It exhibits antiviral effects by preventing the entry of viral particles into the host cells, either by blocking cellular receptors or by direct binding to the virus particles.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1793702/

Lactoferrin as a potential preventative treatment for COVID-19

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many COVID-19 patients develop acute respiratory distress syndrome, which leads to pulmonary edema and lung failure and have liver, heart, and kidney damages.

The antiviral properties of lactoferrin make it a great natural supplement for COVID-19. According to a team of researchers led by the University of Huddersfield, LF has the potency to be used as an adjunct for COVID-19 and various other respiratory tract infections. Furthermore, LF possesses unique immunomodulatory and anti-inflammatory effects and may be effective in COVID-19 treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390755/
https://pubmed.ncbi.nlm.nih.gov/34620326/

What makes lactoferrin a super-ingredient?

Lactoferrin has a significant role in the immune system. It influences the immune cells as most of these cells have LF receptors. It can exert changes on white blood cells by increasing natural killer cells, neutrophils, and macrophage activities. Consequently, the production of immune modulators like cytokine and nitric oxide increases.

LF seems to induce a soothing effect in the body, which is why infants almost always fall asleep after nursing. Hence, LF can be used in individuals who have a significant amount of stress. Although sleep can improve physical stress, emotional stress is not that easy to address. Psychological stress is one of the worst things to cope with, and LF can help reduce the burden of this kind of stress. Not only this, LF has various roles throughout the body, which makes it a super-ingredient.

Marker of Inflammation and Infections

Lactoferrin kills bacteria and protects from infections. Therefore, natural lactoferrin levels in our bodies rise during times of infections and inflammation.

Antioxidant Properties

Although iron and copper are necessary minerals for the body, free iron or copper ions act as catalysts to produce hydroxyl radicals. The hydroxyl radical (-OH) is a free radical with the most active chemical properties. It is also known as Reactive Oxygen Species (ROS) and can severely damage cell membranes. Its oxidative power is greater than the 10th power of 10.

Vitamin C and Vitamin E are natural antioxidants. But, lactoferrin is superior to vitamins C and E in eliminating hydroxyl radicals. LF can bind to these unstable free iron and copper ions, thereby inhibiting the production of hydroxyl radicals. This way, LF reduces oxidative stress and prevents cell damage or cell death.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915836/

Maintains bone density

Lactoferrin promotes osteoblast (bone-forming cells) growth and inhibits osteoblast apoptosis (the death of bone-forming cells). It inhibits osteoclast precursor cells from differentiating into mature osteoclasts. Through these dual activities, LF can help prevent the loss of bone density.

Lactoferrin and Dry Eyes

Dry eyes are an ever-increasing problem in the current digital era, which has raised in the pandemic. Because lactoferrin exists in tears, the speculation is that it has a role in producing tears. Through its unique combination of antimicrobial action and anti-inflammatory activities, LF in the tear plays a vital role in the maintenance of ocular health.

Cancer treatment support

Lactoferrin supports the immune system by activating microbe and cancer-fighting cells such as natural killer cells and T lymphocytes.

Lactoferrin and interferon

Lactoferrin stimulates interferon production. The inventor of enteric-coated lactoferrin had discovered this fact. Earlier, he had worked in a large pharmaceutical company that produces interferon drugs for hepatitis. As a matter of conscience, he resigned from the drug company because his discovery was potentially financially disadvantageous to the company.

Because lactoferrin is a natural substance, the company could not hold a patent on the discovery. It is very affordable compared to the expensive drugs produced by Big Pharma. It creates the same effect of upregulation of interferon production. LF has the potential to make obsolete extremely costly drugs, which induce the production of interferon.

(Tanaka K, Ikeda M, Nozaki A, et al. Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study. Jpn J Cancer Res 90:367-371, 1999).

Lactoferrin should not be confused with whey and colostrums.

People often ask if lactoferrin is more potent than conventional whey protein. Yes, it is. Many of the products used for body-building contain whey protein isolate, which has less than 10% lactoferrin.

Moreover, most of the proteins get denatured during the production process. The lactoferrin contained in these products cannot exert its biological functions adequately. Every year more than 200 scientific papers focusing on lactoferrin are published. But, there are very few articles about whey proteins.

Something to be aware of is that people frequently confuse lactoferrin with colostrum. Colostrum only has small amounts of lactoferrin and doesn’t function in adults.

Are lactoferrin and apolactoferrin the same thing?

Recently, apolactoferrin, a synthetic form of lactoferrin, has been popular on the market. But, this so-called artificial lactoferrin does not contain iron and is basically the original lactoferrin without iron.

Apolactoferrin claims its efficacy with its theory. However, natural lactoferrin has a remarkable effect on our body because it contains 20% iron. It is against the law of nature to remove it. Nature itself, or something as close to nature as possible, is safe and effective most of the time. Hence, we don’t recommend apolactoferrin.

Why is it enteric coated?

Lactoferrin is relatively stable in the gastrointestinal tract in neonates. However, when administered orally to adults, it is degraded and limits its efficacy.

The most important aspect is to inhibit the decomposition of LF in the stomach and duodenum. Using an enteric coating creates a barrier that protects against peptic digestion during oral delivery of lactoferrin. It allows the delivery of a biologically active whole molecule to its optimum site of adsorption or absorption, such as the small intestine.

If lactoferrin cannot reach the small intestine, it is pointless to take it. The breastmilk that infants nurse metabolizes into chunks of curds and whey in their stomachs. Here, the whey with the LF transports to their intestines. That is the only form of lactoferrin that is effective.

The best lactoferrin supplement is enteric-coated. Even though the enteric-coated form of lactoferrin is more expensive, other preparations decompose before they reach the intestine and have no value.

The post Doctors Mega Lactoferrin – 120 Enteric-coated tablets appeared first on Makise Lifeup USA.

Egoma Oil (Perilla Seed Oil)

CustomerTeam — Fri, 01 May 2020 04:33:39 +0000

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

Perilla frutescens (Perilla) is an annual plant native to Southeast Asia. Also known as egoma in Japanese, it falls under one of the 50 fundamental herbs in Traditional Chinese Medicine(TCM).

Egoma oil is one of the best-known and most utilized oils in Japan. For about 800 years until the late Edo period (1603-1868), people mostly used Egoma oil. After the years, rapeseed oil was widespread nationwide. Then, in the 1990s, Egoma oil became favored as a health supplement, especially in the Far East. It was because of its high content of α-linolenic acid (omega-3 unsaturated fatty acid).

Since ancient times, local people of Japan, like from Karumai town, cultivated perilla.

Traditionally, people call it “junnen”, which literal translation is ten years. There is a belief in Japan that consuming perilla will make you live longer. The name is hence derived, for if you eat it, you will live ten years longer.

What Makes Egoma Seed Oil So Special?

The oil of Egoma is rich in essential polyunsaturated fatty acids. Our body cannot synthesize these fatty acids, and diets are the only source.

In contrast to other seed oils, Egoma oil contains the highest proportion of omega-3 fatty acids. Its omega-3 fatty acid is alpha-linolenic acid (ALA) and is 60% to 70% in proportion. It also contains vital omega-6 and omega-9 fatty acids.

Eicosanoid is the final substance produced in the cell membrane from essential fatty acids. It has 20 carbon atoms in the skeleton that acts as a powerful hormone in and around the cell. The essential fatty acids promote the production of benign eicosanoids. They also suppress the production of malignant eicosanoids.

Effects of benign eicosanoids: Anti-inflammation, vasodilation, platelet aggregation suppression, immune system enhancement, cancer suppression, allergy symptom relief

Effects of malignant eicosanoids: Pro-inflammation, vasoconstriction, promotion of platelet aggregation, decrease the immune system, allergic symptoms

Egoma oil is also abundant in rosmarinic acid.

Rosmarinic acid is a kind of polyphenol contained in Lamiaceae herbs. It has a structure in which an ester bond links two caffeic acids. Rosmarinic acid is a natural antioxidant with a health effect similar to tannin.

Effects of Rosmarinic acid

Prevents a decline in brain function. Very promising to alleviate Alzheimer’s disease.
Suppress allergic diseases such as asthma, hay fever, atopic dermatitis.
Improves insulin sensitivity.
Inhibits the digestive enzyme “maltase”, which helps to suppress the rise in blood sugar levels.
Antibacterial and antiviral effects

In addition to rosmarinic acid, perilla seed oil contains apigenin and luteolin. Both are a flavone, a type of flavonoid, with a yellow crystalline appearance.

Apigenin: Recent research shows that Apigenin stimulates the production of new brain cells. It enhances the function of synapses involved in human neural activity.

Luteolin: Luteolin is a flavonoid found in citrus fruits. It is also present in Perilla, one of the best cancer fighters ever. It inhibits aromatase that activates estrogen biosynthesis. Thus, it is potential for estrogen-dependent cancers prevention, such as breast cancer.

Some Others Health Effects and Benefits of Egoma Oil

This oil has recently been attracting attention from people who care about health. You get many benefits from this oil if you add it regularly to your diet. Here are some of the health effects and benefits of perilla seed oil

Egoma Oil for Heart Health

Studies have shown that Egoma oil can help the cardiovascular system. This oil is high in omega-3 fatty acids that are beneficial for lowering cholesterol levels. This oil can improve blood circulation, the functionality of the heart and improve many heart disease risk factors.

Egoma for Brain and Memory Health

Studies show that Egoma oil can improve memory and the ability to concentrate. Omega-3 of this oil can reduce anxiety and depression. It helps improve the ability to focus, concentrate, and memory. Because of the anti-inflammatory effect of Egoma oil, it can also help to reduce inflammation in the brain. The daily intake of Egoma oil reduces the risk of Alzheimer’s disease and can help decrease age-associated cognitive decline.

Egoma Oil for Skin

It is a great supplement that helps to keep your skin healthy. It can even reverse the appearance of skin aging to give you beautiful, healthy, and youthful skin. This oil is rich in antioxidant that helps to get rid of free radicals. It also helps in the prevention of skin damage and with skin conditions like eczema and psoriasis.

Egoma Oil for Immune System

The human immune system is incredible. It keeps us safe from invaders such as bacteria, viruses, and other pathogens. Adding Egoma oil to the diet builds a robust immune system. This oil provides the right amount of antioxidants to help your body work right. Moreover, they can help eliminate the free radicals in your body.

Egoma Oil from a Diet Perspective

Egoma oil is beneficial for our health. It helps in burning accumulated fats, which helps in preventing obesity. Unlike general oils, Egoma oil is effective for weight management. The rosmarinic acid present in this oil helps prevent the absorption of excess sugar in the body. Consequently, it controls a rise in blood sugar.

But this is not the only reason to add Egoma oil to a healthy diet. It prevents inflammation, high blood pressure, stroke, and diabetes. It also reduces the risk of getting certain forms of cancer. Therefore, Egoma oil is a superfood with several advantages and benefits.

Recommended Ways to Eat Egoma Oil

Our sachet pack is very convenient to use. You can take a sachet directly or mix it with other foods. Here are some recommended ways to eat our Egoma oil.

According to the Japanese Ministry of Health, Labor, and Welfare, the standard daily intake of omega-3 fatty acids (adult) is 1.6 to 2.4 g per day.

You have to eat about three horse mackerel (120g per fish) to acquire the fatty acids. But you can achieve this healthy target with only one sachet of Egoma oil.
Our Egoma oil contains 100% pure cold-pressed perilla seed oil with no added antioxidant. It is the best natural plant alternative to essential omega-3 fatty acids.

It is presently gaining global recognition because of its antioxidant, anti-aging, antiseptic, and anti-allergic properties. The results of all these benefits make it well worth trying.

Dr.Makise’s Choice

Americans and Europeans are not so familiar with perilla seed oil. (In Japan, known as Egoma oil). But, the health-promoting effects of this oil are much more versatile than Flaxseed Oil.

In my daily life, instead of three omega-3 gel capsules of 1000mg, I take one sachet = 3g of this perilla seed oil with juice, soup, or meal. We don’t have to take unnecessary gel ingredients to meet essential fatty acids requirements.

And above all, it is delicious, portable, and does not get oxidized easily. I would like to introduce our Egoma seed oil (perilla seed oil) to you.

Ingredients
Cold-pressed extra virgin perilla seed oil

Package Quantity
3g per sachet / 30 sachets per bottle

Suggested Use
1 sachet daily with or without food

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The New JIPANG Ginger OPTIMAL

Shell Ginger (Alpinia zerumbet) is a tropical perennial herb. In Japan, it has been consumed for centuries, especially in Okinawa Prefecture. The people of Okinawa is often cited as “the healthiest on Earth,” boasting remarkably low rates of cardiovascular diseases, strokes, and cancer.

The new JIPANG Ginger OPTIMAL has been enhanced with a potent blend that adds Ellagic Acid and Ferulic Acid to the polyphenols found in Shell Ginger. This improved formula is designed to contribute even more to your health and well-being.

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Supplement – Makise Lifeup USA

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Wasabi

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JIPANG Ginger PROTEOGLYCAN – 60 Vegetable Capsules

Japanese doctor's supplement

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What is Proteoglycan?

Proteoglycan is extracted from Salmon nasal cartilage“氷頭 - HIZU"

Revolutionary effect of “PROTEOGLYCAN”

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Total Vitality Pack

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Does Shell Ginger Promote Longevity?

High in Antioxidants​

Full of Healthy Polyphenols - 34 Times more Polyphenols than Red Wine

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Red Vine Leaf – Healthy Vein Circulation 120 capsules (30 capsules x 4 packets)

Japanese doctor's supplement

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Proteor GII (Proteoglycan supplement) – 90 Tablets

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

What is Proteoglycan?

What are Proteor-GII supplements made up of?

Health benefits of Proteoglycan

Proteoglycan is the main component contributing to the elasticity of the articular cartilage

Proteoglycan supports joint movement

Proteoglycan supplement has shown promising benefits, especially in the case of osteoarthritis.

Along with joint health, Proteoglycan has several physiological functions

Other benefits of Proteoglycans

Is Proteoglycan different from Collagen or Hyaluronic acid?

Should I take Glucosamine for my osteoarthritis?

Doctors Mega Lactoferrin – 120 Enteric-coated tablets

Japanese doctor's supplement

We deliver products that you can continue to use with peace of mind.

We Have Taken Lactoferrin Since Our First Feed.

What is Lactoferrin?

The first immunization of humans

Lactoferrin and its iron-binding properties

Antimicrobial properties of lactoferrin

High in Antioxidants