PROTEALL GⅡ
A Japanese proteoglycan formula for everyday joint mobility.
Built around salmon nasal cartilage-derived proteoglycan, with four complementary cartilage and matrix-supporting ingredients in a simple three-tablet daily serving.
- 10 mg proteoglycan per day
- Five key ingredients
- 90 tablets / 30 days
- Three tablets daily
- Manufactured in Japan
- Japan FFC Notification F235
Notification
F235
Notification number
Scientific evidence disclosed under Japan’s FFC system.
In Japan, PROTEALL GⅡ is notified as a Foods with Function Claims product. The notified functional ingredient is salmon nasal cartilage-derived proteoglycan.
The Japanese notification describes research relating to cartilage metabolism and everyday knee movement in adults with knee discomfort.
Japan’s FFC system is a notification system and is not equivalent to FDA approval. This product has not been evaluated or approved by the U.S. Food and Drug Administration.
What is hizu?
Hizu is the soft cartilage found in the snout of a salmon. Because of its translucent, ice-like appearance, it became known in Japanese as “hizu,” literally “ice head.”
In northern regions of Japan, thinly sliced hizu has traditionally been prepared with vinegar and served as a regional dish. Today, salmon nasal cartilage is also valued as a source of proteoglycan.
A familiar Japanese ingredient, seen in a new way.
The traditional use of hizu reflects a long relationship between Japanese food culture and salmon cartilage. Modern extraction technology has made it possible to prepare salmon nasal cartilage-derived proteoglycan as a standardized food ingredient.
Traditional food use does not, by itself, establish a clinical effect. Research information is presented separately below.
Proteoglycan-centered, thoughtfully combined.
The formal ingredient names below follow the current product formulation. Amounts shown are per recommended daily serving of three tablets.
Proteoglycan is not collagen or hyaluronic acid.
Collagen contributes structural strength to the extracellular matrix. Hyaluronic acid attracts and retains water. Proteoglycans are glycoproteins with glycosaminoglycan chains and are also important components of the extracellular matrix.
These substances work within the same biological environment, but they are structurally different.
Educational description of biological components; it does not establish that consuming the finished product changes human tissue.
A water-rich extracellular matrix.
Articular cartilage is composed largely of water, together with type II collagen fibers, proteoglycans, cartilage cells, and smaller amounts of other matrix components.
The proportions shown are educational ranges. Actual composition varies by cartilage region, age, health status, and measurement method.
10 mg per day for 16 weeks.
A randomized, double-blind, placebo-controlled study evaluated salmon nasal cartilage-derived proteoglycan in Japanese adults with knee discomfort who had not been diagnosed with knee osteoarthritis.
Randomized and placebo-controlled
Sixty adults were enrolled and 55 were included in the efficacy analysis. Participants consumed 10 mg of salmon nasal cartilage proteoglycan or placebo daily for 16 weeks.
The subgroup result needs context
The full-group analysis did not show a significant between-group difference in C1,2C or PIICP. A significant C1,2C difference was reported in a subgroup with a JKOM total score of 41 or higher.
Reference: Tomonaga A, Takahashi T, Tanaka YT, et al. Experimental and Therapeutic Medicine. 2017;14:115–126. DOI: 10.3892/etm.2017.4454.
Research notice: The published trial evaluated a salmon nasal cartilage proteoglycan test supplement. Research results do not guarantee individual outcomes and should not be interpreted as proof of cartilage regrowth or treatment of disease.
Made in Japan for a simple daily routine.
PROTEALL GⅡ combines five selected ingredients in a three-tablet daily serving.
Three tablets, once daily.
Take three tablets daily
Use the recommended daily serving unless otherwise advised by a qualified healthcare professional.
Take with water
Swallow with water or another suitable beverage. Do not exceed the suggested serving.
Make it a routine
Each bottle contains 90 tablets, providing a 30-day supply at three tablets per day.
PROTEALL GⅡ
90 tablets · 30-day supply · Made in Japan
Buy on Our Secure StoreFrequently asked questions.
What does Japan FFC Notification F235 mean?
Japan’s Foods with Function Claims system allows a responsible business operator to notify the Consumer Affairs Agency of a function claim supported by submitted scientific evidence. It is not individual government approval and is not equivalent to FDA approval.
How much proteoglycan does the product provide?
The recommended daily serving of three tablets provides 10 mg of salmon nasal cartilage-derived proteoglycan.
Is proteoglycan the same as collagen or hyaluronic acid?
No. They are different components of the extracellular matrix. PROTEALL GⅡ contains a proteoglycan ingredient as well as porcine cartilage extract and hyaluronic acid.
Does the product contain animal-derived ingredients?
Yes. It contains ingredients derived from salmon, shrimp/crab, pork, and shark cartilage. Review the product label carefully if you have food allergies or dietary restrictions.
Who should consult a healthcare professional before use?
Consult a qualified healthcare professional before use if you are pregnant, nursing, trying to conceive, under 18, have a medical condition, take medication, or have a known food allergy.
U.S. dietary supplement notice: These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children. Store tightly closed in a cool, dry place away from direct sunlight. Discontinue use and consult a healthcare professional if an adverse reaction occurs.
Japan FFC Notification F235 is a notification under Japan’s Foods with Function Claims system; it does not represent approval by the U.S. FDA.
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